See Pubmed for full publication list |
Mowat CV, Mosley SR, Namdar A, Schiller D, Baker K. Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires IFN-driven CCL5 and CXCL10. J Exp Med. 6 September 2021; 218 (9): e20210108. doi: https://doi.org/10.1084/jem.20210108. PMID: 34297038.
Hubbard JJ, Pyzik M, Rath T, Kozicky LK, Sand KMK, Gandhi AK, Grevys A, Foss S, Menzies SC, Glickman JN, Fiebiger E, Roopenian DC, Sandlie I, Andersen JT, Sly LM, Baker K*, Blumberg RS*. FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex–driven autoimmunity. J Exp Med. 5 October 2020; 217 (10): e20200359. doi: https://doi.org/10.1084/jem.20200359. PMID: 32658257. *Equally contributing senior/corresponding authors.
Newell M, Mackey JR, Bigras G, Alvarez-Camacho M, Goruk S, Ghosh S, Schmidt A, Miede D, Chisotti A, Postovit L, Baker K, Mazurak V, Courneya K, Berendt R, Dong WF, Wood G, Basi SK, Joy AA, King K, Meza-Junco J, Zhu X, Field CJ. Comparing docosahexaenoic acid (DHA) concomitant with neoadjuvant chemotherapy versus neoadjuvant chemotherapy alone in the treatment of breast cancer (DHA WIN): protocol of a double-blind, phase II, randomised controlled trial. BMJ Open. 2019;9:e030502. doi: 10.1136/bmjopen-2019-030502. PMID: 31530611.
Melum E, Jiang X, Baker K, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S*, Blumberg RS*. Acid sphingomyelinase regulation of sphingomyelin modulates CD1d-restricted antigen presentation and NKT cell dependent inflammation. Nat Immunol. 2019;20:1644-55. doi:10.1038/s41590-019-0504-0. PMID: 31636468.
Baker K. Organoids Provide an Important Window on Inflammation in Cancer. Cancers. 2018;10:151. doi: 10.3390/cancers10050151. PMID: 29883385.
Lozano NA, Lozano A, Marini V, Saranz RJ, Blumberg RS, Baker K, Agresta MF, Ponzio MF. Expression of FcRn receptor in placental tissue and its relationship with IgG levels in term and preterm newborns. Am J Reprod Immunol. 2018;0:e12972. PMID: 29745444.
Nguyen S, Baker K, Padman BS, Patwa R, Dunstan RA, Weston TA, Schlosser K, Bailey B, Lithgow T, Lazarou M, Luque A, Rohwer F, Blumberg RS, Barr JJ. Bacteriophage transcytosis provides a mechanism to cross epithelial cell layers. mBio. 2017;8:e01874-17. PMID: 29295916.
Newell M, Baker K, Postovit LM, Field CJ. A Critical Review on the Effect of Docosahexaenoic Acid (DHA) on Cancer Cell Cycle Progression. Int J Mol Sci. 2017;18:1784. PMID: 28817068.
Fernando E, Dicay M, Stahl M, Gordon M, Vegso A, Baggio C, Alston L, Lopes F, Baker K, Hirota S, McKay D, Vallance B, and MacNaughton W. A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2017;313:G467-G475. PMID: 28751424.
Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Kramer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci USA. 2017;114(14):E2862-E2871. PMID: 28330995.
Pyzik M, Rath T, Lencer WI, Baker K, Blumberg RS. FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin. J Immunol. 2015;194(10):4595-4603. PMID: 25934922.
Li L, Hamel N, Baker K, McGuffin MJ, Couillard M, Gologan A, Marcus VA, Chodirker B, Chudley A, Stefanovici C, Durandy A, Hegele RA, Feng BJ, Goldgar DE, Zhu J, De Rosa M, Gruber SB, Wimmer K, Young B, Chong G, Tischkowitz MD, Foulkes WD. A homozygous PMS2 founder mutation with an attenuated constitutional mismatch repair deficiency phenotype. J Med Genet. 2015 Feb 17. PMID: 25691505.
Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KT, Anthony RM, Blumberg RS, Turley SJ, Fiebiger E. IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses. Cell Rep. 2015 Mar 3. pii: S2211-1247(15)00143-6. PMID: 25753415.
Platzer B, Baker K, Vera MP, Singer K, Panduro M, Lexmond WS, Turner D, Vargas SO, Kinet J-P, Maurer D, Baron RM, Blumberg RS, Fiebiger E. Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites. Mucosal Immunol 2014; Sep 17. PMID: 25227985.
Baker K, Rath T, Flak MB, Arthur JC, Chen Z, Glickman JN, Stachler MD, Odze RD, Lencer WI, Jobin C, Blumberg RS. Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer. Immunity 2013;39(6):1095-1107. PMID: 24290911.
Chen Z*, Chen L*, Baker K, Olszak T, Zeissig S, Huang YH, Kuo TT, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. J Exp Med 2011;208(13):2633-40. PMID: 22143889. *Equally contributing.
Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen J-T, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS. FcRn regulates cross-presentation of IgG immune complexes by inflammatory dendritic cells. Proc Natl Acad Sci USA Jun 14;108(24):9927-32. Epub 2011 May 31. PMID: 21628593.
Baker K, Foulkes WD, Jass JR. MSI-H colorectal cancers preferentially retain and expand intraepithelial lymphocytes rather than peripherally derived CD8+ T cells. Cancer Immunol Immunother 2009;58:135-44. PMID: 18488217.
Baker K, Raut P, Jass JR. Microsatellite unstable colorectal cancers with truncating TGFbetaRII mutations remain sensitive to endogenous TGFβ. J Pathol 2007;213:257-65. PMID: 17893910.
Baker K, Zlobec I, Tornillo L, Terracciano L, Jass JR, Lugli A. Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: A potential role for dysregulation of the transforming growth factor-beta pathway. Eur J Cancer 2007;43: 624-31. PMID: 17223543.
Baker K, Chong G, Foulkes WD, Jass JR. Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes. Histopathology 2006;49:371-80. PMID: 16978200.
Hubbard JJ, Pyzik M, Rath T, Kozicky LK, Sand KMK, Gandhi AK, Grevys A, Foss S, Menzies SC, Glickman JN, Fiebiger E, Roopenian DC, Sandlie I, Andersen JT, Sly LM, Baker K*, Blumberg RS*. FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex–driven autoimmunity. J Exp Med. 5 October 2020; 217 (10): e20200359. doi: https://doi.org/10.1084/jem.20200359. PMID: 32658257. *Equally contributing senior/corresponding authors.
Newell M, Mackey JR, Bigras G, Alvarez-Camacho M, Goruk S, Ghosh S, Schmidt A, Miede D, Chisotti A, Postovit L, Baker K, Mazurak V, Courneya K, Berendt R, Dong WF, Wood G, Basi SK, Joy AA, King K, Meza-Junco J, Zhu X, Field CJ. Comparing docosahexaenoic acid (DHA) concomitant with neoadjuvant chemotherapy versus neoadjuvant chemotherapy alone in the treatment of breast cancer (DHA WIN): protocol of a double-blind, phase II, randomised controlled trial. BMJ Open. 2019;9:e030502. doi: 10.1136/bmjopen-2019-030502. PMID: 31530611.
Melum E, Jiang X, Baker K, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S*, Blumberg RS*. Acid sphingomyelinase regulation of sphingomyelin modulates CD1d-restricted antigen presentation and NKT cell dependent inflammation. Nat Immunol. 2019;20:1644-55. doi:10.1038/s41590-019-0504-0. PMID: 31636468.
Baker K. Organoids Provide an Important Window on Inflammation in Cancer. Cancers. 2018;10:151. doi: 10.3390/cancers10050151. PMID: 29883385.
Lozano NA, Lozano A, Marini V, Saranz RJ, Blumberg RS, Baker K, Agresta MF, Ponzio MF. Expression of FcRn receptor in placental tissue and its relationship with IgG levels in term and preterm newborns. Am J Reprod Immunol. 2018;0:e12972. PMID: 29745444.
Nguyen S, Baker K, Padman BS, Patwa R, Dunstan RA, Weston TA, Schlosser K, Bailey B, Lithgow T, Lazarou M, Luque A, Rohwer F, Blumberg RS, Barr JJ. Bacteriophage transcytosis provides a mechanism to cross epithelial cell layers. mBio. 2017;8:e01874-17. PMID: 29295916.
Newell M, Baker K, Postovit LM, Field CJ. A Critical Review on the Effect of Docosahexaenoic Acid (DHA) on Cancer Cell Cycle Progression. Int J Mol Sci. 2017;18:1784. PMID: 28817068.
Fernando E, Dicay M, Stahl M, Gordon M, Vegso A, Baggio C, Alston L, Lopes F, Baker K, Hirota S, McKay D, Vallance B, and MacNaughton W. A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2017;313:G467-G475. PMID: 28751424.
Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Kramer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci USA. 2017;114(14):E2862-E2871. PMID: 28330995.
Pyzik M, Rath T, Lencer WI, Baker K, Blumberg RS. FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin. J Immunol. 2015;194(10):4595-4603. PMID: 25934922.
Li L, Hamel N, Baker K, McGuffin MJ, Couillard M, Gologan A, Marcus VA, Chodirker B, Chudley A, Stefanovici C, Durandy A, Hegele RA, Feng BJ, Goldgar DE, Zhu J, De Rosa M, Gruber SB, Wimmer K, Young B, Chong G, Tischkowitz MD, Foulkes WD. A homozygous PMS2 founder mutation with an attenuated constitutional mismatch repair deficiency phenotype. J Med Genet. 2015 Feb 17. PMID: 25691505.
Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KT, Anthony RM, Blumberg RS, Turley SJ, Fiebiger E. IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses. Cell Rep. 2015 Mar 3. pii: S2211-1247(15)00143-6. PMID: 25753415.
Platzer B, Baker K, Vera MP, Singer K, Panduro M, Lexmond WS, Turner D, Vargas SO, Kinet J-P, Maurer D, Baron RM, Blumberg RS, Fiebiger E. Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites. Mucosal Immunol 2014; Sep 17. PMID: 25227985.
Baker K, Rath T, Flak MB, Arthur JC, Chen Z, Glickman JN, Stachler MD, Odze RD, Lencer WI, Jobin C, Blumberg RS. Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer. Immunity 2013;39(6):1095-1107. PMID: 24290911.
Chen Z*, Chen L*, Baker K, Olszak T, Zeissig S, Huang YH, Kuo TT, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. J Exp Med 2011;208(13):2633-40. PMID: 22143889. *Equally contributing.
Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen J-T, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS. FcRn regulates cross-presentation of IgG immune complexes by inflammatory dendritic cells. Proc Natl Acad Sci USA Jun 14;108(24):9927-32. Epub 2011 May 31. PMID: 21628593.
Baker K, Foulkes WD, Jass JR. MSI-H colorectal cancers preferentially retain and expand intraepithelial lymphocytes rather than peripherally derived CD8+ T cells. Cancer Immunol Immunother 2009;58:135-44. PMID: 18488217.
Baker K, Raut P, Jass JR. Microsatellite unstable colorectal cancers with truncating TGFbetaRII mutations remain sensitive to endogenous TGFβ. J Pathol 2007;213:257-65. PMID: 17893910.
Baker K, Zlobec I, Tornillo L, Terracciano L, Jass JR, Lugli A. Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: A potential role for dysregulation of the transforming growth factor-beta pathway. Eur J Cancer 2007;43: 624-31. PMID: 17223543.
Baker K, Chong G, Foulkes WD, Jass JR. Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes. Histopathology 2006;49:371-80. PMID: 16978200.